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| School | Address | City | Zip | Phone | Fax | UIL Director |
| La Joya UIL | 604 N Coyote Dr | La Joya | 78560 | 580-5185 | 580-5186 | E. Nena Garza |
| Brownsville UIL | 708 Palm Blvd | Brownsville | 78520 | 698-0847 | 548-8294 | Stephen Shull |
| Hanna HS | 2615 Price Rd | Brownsville | 78520 | 548-7600 | 548-7644 | Richard Rodriguez |
| Lopez HS | 3205 S Dakota | Brownsville | 78520 | 982-7400 | 982-7499 | Mary Ann Flores |
| Pace HS | 314 W Los Ebanos | Brownsville | 78520 | 548-7700 | 548-7710 | Denise Rodriguez |
| Porter HS | 3500 International | Brownsville | 78520 | 546-4094 | 982-2892 | Christina Cavazos |
| Rivera HS | 6955 FM 802 | Brownsville | 78520 | 831-8737 | 831-8761 | Fernando Reyes |
| Donna HS | 1/4 Mile E Wood | Donna | 78537 | 464-1700 | 464-1629 | Rosie Zuniga |
| Edcouch-Elsa | POB 127 | Edcouch | 78528 | 262-4731 | 262-4694 | Diana Cardenas |
| Edinburg HS | 2600 E Wisconsin R | Edinburg | 78539 | 289-2400 | 386-1103 | Tommy Green . |
| Edinburg North | 3101 N Closner | Edinburg | 78539 | 316-7654 | 316-7712 | Manuel Saenz |
| Edinburg Economedes | 1414 N Alamo Rd | Edinburg | 78539 | 385-3000 | 385-3050 | Dalisa Montemayor |
| B.E.T.A. | 510 S Sugar Rd | Edinburg | 78539 | 383-1684 | 383-8544 | Diana Chavez |
| Harlingen HS | 1201 E Marshall | Harlingen | 78550 | 427-3600 | 427-3792 | L. Black |
| Harlingen South | 1701 Dixieland | Harlingen | 78550 | 427-3800 | 427-3995 | Lee Ann Ince |
| Hidalgo HS | 910 Pirate Dr | Hidalgo | 78557 | 843-3160 | 843-7035 | Diane Waring |
| La Feria HS | 500 N Canal St | La Feria | 78559 | 797-1353 | 797-9374 | Sherry Stewart |
| La Villa HS | La Villa | 262-9798 | Juan Garay | |||
| Lyford HS | PO Drawer 220 | Lyford | 78569 | 347-3521 | 347-5201 | |
| McAllen HS | 2021 La Vista | McAllen | 78501 | 632-3164 | 632-3114 | Diana Rodriguez |
| McAllen Memorial | 101 E Hackberry | McAllen | 78501 | 632-5201 | 632-5226 | Bill Hetrick |
| McAllen Rowe | 2101 Ware Rd | McAllen | 78501 | 632-5100 | 632-8850 | Keith Arney |
| Mercedes HS | 1200 S Florida | Mercedes | 78570 | 514-2100 | 514-2015 | Robert Root |
| Science Academy | 900 Med High | Mercedes | 78570 | 565-2454 | 565-9112 | David Wood |
| HS for Health Prof | 700 Med High | Mercedes | 78570 | 565-2454 | 565-4039 | Santos Esquivel |
| Mission HS | 1802 Cleo Dawson | Mission | 78572 | 580-5725 | 580-5890 | Veronica Anzaldua |
| Mission Veterans | 700 E 2 Mile Rd | Mission | 78572 | 323-3000 | 323-3280 | Miguel Alanis |
| Sharyland HS | 1106 N Shary Rd | Mission | 78572 | 580-5300 | 580-5311 | Diamantina Chapa |
| Valley View HS | Rt 1 Box 122 | Pharr | 78577 | 843-9261 | 843-5002 | Sandra Garza |
| Port Isabel HS | PO Drawer H | Port Isabel | 78578 | 943-0041 | 943-0048 | Juan Rivera |
| Progreso HS | POB 613 | Progreso | 78579 | 565-4142 | 565-2128 | Teresa Rodriguez |
| P-SJ-A HS | 805 W Ridge Rd | San Juan | 78589 | 783-2252 | 783-2293 | Ofelia Pena |
| P-SJ-A Memorial | 800 S Alamo Rd | Alamo | 78516 | Robert Gomez | ||
| P-SJ-A North | 500 E Nolana | Pharr | 78577 | Luis Suarez | ||
| Raymondville HS | 1 Bearkat Blvd | Rayomondville | 78580 | 689-2471 | 689-6587 | |
| Rio Grande City HS | Fort Ringgold | Rio Grande City | 78582 | Velma Guerrero | ||
| Rio Hondo HS | POB 220 | Rio Hondo | 78583 | 748-4500 | 748-4408 | Edwin Everitt |
| Roma HS | POB 187 | Roma | 78584 | 849-1333 | 849-2655 | |
| San Benito HS | 450 S William Rd | San Benito | 78586 | 361-6500 | 361-6508 | |
| San Isidro HS | FM 1017 | San Isidro | 78588 | 481-3930 | Anna Garcia | |
| Santa Maria HS | POB 448 | Santa Maria | 78592 | 565-9144 | 565-4422 | |
| Santa Rosa HS | POB 368 | Santa Rosa | 78593 | 636-1811 | 636-1139 | |
| Weslaco HS | 1005 W Pike Dr | Weslaco | 78596 | 969-6700 | 968-8008 | Diana Hicks |
| Weslaco East HS | 810 S Pleasantview | Weslaco | 78596 | 969-6950 | 968-8693 | Vernon Einhorn |